PDB 5lf4

PDB Links
Overview

PDB Information

PDB	5LF4
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-30
Resolution	1.990
CATH Insert Date	04 Sep, 2016

PDB Images (57)

5lf4

PDB 5lf4

5lf4a

PDB Chain 5lf4a

5lf4A

PDB Chain 5lf4A

5lf4b

PDB Chain 5lf4b

5lf4B

PDB Chain 5lf4B

5lf4C

PDB Chain 5lf4C

5lf4D

PDB Chain 5lf4D

5lf4E

PDB Chain 5lf4E

5lf4F

PDB Chain 5lf4F

5lf4G

PDB Chain 5lf4G

5lf4H

PDB Chain 5lf4H

5lf4I

PDB Chain 5lf4I

5lf4J

PDB Chain 5lf4J

5lf4K

PDB Chain 5lf4K

5lf4L

PDB Chain 5lf4L

5lf4M

PDB Chain 5lf4M

5lf4N

PDB Chain 5lf4N

5lf4O

PDB Chain 5lf4O

5lf4P

PDB Chain 5lf4P

5lf4Q

PDB Chain 5lf4Q

5lf4R

PDB Chain 5lf4R

5lf4S

PDB Chain 5lf4S

5lf4T

PDB Chain 5lf4T

5lf4U

PDB Chain 5lf4U

5lf4V

PDB Chain 5lf4V

5lf4W

PDB Chain 5lf4W

5lf4X

PDB Chain 5lf4X

5lf4Y

PDB Chain 5lf4Y

5lf4Z

PDB Chain 5lf4Z

5lf4a00

CATH Domain 5lf4a00

5lf4A00

CATH Domain 5lf4A00

5lf4b00

CATH Domain 5lf4b00

5lf4B00

CATH Domain 5lf4B00

5lf4C00

CATH Domain 5lf4C00

5lf4D00

CATH Domain 5lf4D00

5lf4E00

CATH Domain 5lf4E00

5lf4F00

CATH Domain 5lf4F00

5lf4G00

CATH Domain 5lf4G00

5lf4H00

CATH Domain 5lf4H00

5lf4I00

CATH Domain 5lf4I00

5lf4J00

CATH Domain 5lf4J00

5lf4K00

CATH Domain 5lf4K00

5lf4L00

CATH Domain 5lf4L00

5lf4M00

CATH Domain 5lf4M00

5lf4N00

CATH Domain 5lf4N00

5lf4O00

CATH Domain 5lf4O00

5lf4P00

CATH Domain 5lf4P00

5lf4Q00

CATH Domain 5lf4Q00

5lf4R00

CATH Domain 5lf4R00

5lf4S00

CATH Domain 5lf4S00

5lf4T00

CATH Domain 5lf4T00

5lf4U00

CATH Domain 5lf4U00

5lf4V00

CATH Domain 5lf4V00

5lf4W00

CATH Domain 5lf4W00

5lf4X00

CATH Domain 5lf4X00

5lf4Y00

CATH Domain 5lf4Y00

5lf4Z00

CATH Domain 5lf4Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
C	05 Sep, 2016	Chopped
D	05 Sep, 2016	Chopped
E	05 Sep, 2016	Chopped
F	05 Sep, 2016	Chopped
G	05 Sep, 2016	Chopped
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lf4a00	09 Sep, 2016	3.60.20.10	Assigned
5lf4A00	09 Sep, 2016	3.60.20.10	Assigned
5lf4b00	20 Oct, 2016	3.60.20.10	Assigned
5lf4B00	09 Sep, 2016	3.60.20.10	Assigned
5lf4C00	09 Sep, 2016	3.60.20.10	Assigned
5lf4D00	09 Sep, 2016	3.60.20.10	Assigned
5lf4E00	09 Sep, 2016	3.60.20.10	Assigned
5lf4F00	09 Sep, 2016	3.60.20.10	Assigned
5lf4G00	09 Sep, 2016	3.60.20.10	Assigned
5lf4H00	09 Sep, 2016	3.60.20.10	Assigned
5lf4I00	09 Sep, 2016	3.60.20.10	Assigned
5lf4J00	09 Sep, 2016	3.60.20.10	Assigned
5lf4K00	09 Sep, 2016	3.60.20.10	Assigned
5lf4L00	09 Sep, 2016	3.60.20.10	Assigned
5lf4M00	09 Sep, 2016	3.60.20.10	Assigned
5lf4N00	20 Oct, 2016	3.60.20.10	Assigned
5lf4O00	09 Sep, 2016	3.60.20.10	Assigned
5lf4P00	09 Sep, 2016	3.60.20.10	Assigned
5lf4Q00	09 Sep, 2016	3.60.20.10	Assigned
5lf4R00	09 Sep, 2016	3.60.20.10	Assigned
5lf4S00	09 Sep, 2016	3.60.20.10	Assigned
5lf4T00	09 Sep, 2016	3.60.20.10	Assigned
5lf4U00	09 Sep, 2016	3.60.20.10	Assigned
5lf4V00	09 Sep, 2016	3.60.20.10	Assigned
5lf4W00	09 Sep, 2016	3.60.20.10	Assigned
5lf4X00	09 Sep, 2016	3.60.20.10	Assigned
5lf4Y00	09 Sep, 2016	3.60.20.10	Assigned
5lf4Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3