PDB 5lf1

PDB Links
Overview

PDB Information

PDB	5LF1
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-30
Resolution	2.000
CATH Insert Date	04 Sep, 2016

PDB Images (57)

5lf1

PDB 5lf1

5lf1a

PDB Chain 5lf1a

5lf1A

PDB Chain 5lf1A

5lf1b

PDB Chain 5lf1b

5lf1B

PDB Chain 5lf1B

5lf1C

PDB Chain 5lf1C

5lf1D

PDB Chain 5lf1D

5lf1E

PDB Chain 5lf1E

5lf1F

PDB Chain 5lf1F

5lf1G

PDB Chain 5lf1G

5lf1H

PDB Chain 5lf1H

5lf1I

PDB Chain 5lf1I

5lf1J

PDB Chain 5lf1J

5lf1K

PDB Chain 5lf1K

5lf1L

PDB Chain 5lf1L

5lf1M

PDB Chain 5lf1M

5lf1N

PDB Chain 5lf1N

5lf1O

PDB Chain 5lf1O

5lf1P

PDB Chain 5lf1P

5lf1Q

PDB Chain 5lf1Q

5lf1R

PDB Chain 5lf1R

5lf1S

PDB Chain 5lf1S

5lf1T

PDB Chain 5lf1T

5lf1U

PDB Chain 5lf1U

5lf1V

PDB Chain 5lf1V

5lf1W

PDB Chain 5lf1W

5lf1X

PDB Chain 5lf1X

5lf1Y

PDB Chain 5lf1Y

5lf1Z

PDB Chain 5lf1Z

5lf1a00

CATH Domain 5lf1a00

5lf1A00

CATH Domain 5lf1A00

5lf1b00

CATH Domain 5lf1b00

5lf1B00

CATH Domain 5lf1B00

5lf1C00

CATH Domain 5lf1C00

5lf1D00

CATH Domain 5lf1D00

5lf1E00

CATH Domain 5lf1E00

5lf1F00

CATH Domain 5lf1F00

5lf1G00

CATH Domain 5lf1G00

5lf1H00

CATH Domain 5lf1H00

5lf1I00

CATH Domain 5lf1I00

5lf1J00

CATH Domain 5lf1J00

5lf1K00

CATH Domain 5lf1K00

5lf1L00

CATH Domain 5lf1L00

5lf1M00

CATH Domain 5lf1M00

5lf1N00

CATH Domain 5lf1N00

5lf1O00

CATH Domain 5lf1O00

5lf1P00

CATH Domain 5lf1P00

5lf1Q00

CATH Domain 5lf1Q00

5lf1R00

CATH Domain 5lf1R00

5lf1S00

CATH Domain 5lf1S00

5lf1T00

CATH Domain 5lf1T00

5lf1U00

CATH Domain 5lf1U00

5lf1V00

CATH Domain 5lf1V00

5lf1W00

CATH Domain 5lf1W00

5lf1X00

CATH Domain 5lf1X00

5lf1Y00

CATH Domain 5lf1Y00

5lf1Z00

CATH Domain 5lf1Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
C	05 Sep, 2016	Chopped
D	05 Sep, 2016	Chopped
E	05 Sep, 2016	Chopped
F	05 Sep, 2016	Chopped
G	05 Sep, 2016	Chopped
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lf1a00	09 Sep, 2016	3.60.20.10	Assigned
5lf1A00	09 Sep, 2016	3.60.20.10	Assigned
5lf1b00	20 Oct, 2016	3.60.20.10	Assigned
5lf1B00	09 Sep, 2016	3.60.20.10	Assigned
5lf1C00	09 Sep, 2016	3.60.20.10	Assigned
5lf1D00	09 Sep, 2016	3.60.20.10	Assigned
5lf1E00	09 Sep, 2016	3.60.20.10	Assigned
5lf1F00	09 Sep, 2016	3.60.20.10	Assigned
5lf1G00	09 Sep, 2016	3.60.20.10	Assigned
5lf1H00	09 Sep, 2016	3.60.20.10	Assigned
5lf1I00	09 Sep, 2016	3.60.20.10	Assigned
5lf1J00	09 Sep, 2016	3.60.20.10	Assigned
5lf1K00	09 Sep, 2016	3.60.20.10	Assigned
5lf1L00	09 Sep, 2016	3.60.20.10	Assigned
5lf1M00	09 Sep, 2016	3.60.20.10	Assigned
5lf1N00	20 Oct, 2016	3.60.20.10	Assigned
5lf1O00	09 Sep, 2016	3.60.20.10	Assigned
5lf1P00	09 Sep, 2016	3.60.20.10	Assigned
5lf1Q00	09 Sep, 2016	3.60.20.10	Assigned
5lf1R00	09 Sep, 2016	3.60.20.10	Assigned
5lf1S00	09 Sep, 2016	3.60.20.10	Assigned
5lf1T00	09 Sep, 2016	3.60.20.10	Assigned
5lf1U00	09 Sep, 2016	3.60.20.10	Assigned
5lf1V00	09 Sep, 2016	3.60.20.10	Assigned
5lf1W00	09 Sep, 2016	3.60.20.10	Assigned
5lf1X00	09 Sep, 2016	3.60.20.10	Assigned
5lf1Y00	09 Sep, 2016	3.60.20.10	Assigned
5lf1Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7