PDB 5lf0

PDB Links
Overview

PDB Information

PDB	5LF0
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-30
Resolution	2.410
CATH Insert Date	04 Sep, 2016

PDB Images (63)

5lf0

PDB 5lf0

5lf0a

PDB Chain 5lf0a

5lf0A

PDB Chain 5lf0A

5lf0b

PDB Chain 5lf0b

5lf0B

PDB Chain 5lf0B

5lf0c

PDB Chain 5lf0c

5lf0C

PDB Chain 5lf0C

5lf0d

PDB Chain 5lf0d

5lf0D

PDB Chain 5lf0D

5lf0e

PDB Chain 5lf0e

5lf0E

PDB Chain 5lf0E

5lf0f

PDB Chain 5lf0f

5lf0F

PDB Chain 5lf0F

5lf0g

PDB Chain 5lf0g

5lf0G

PDB Chain 5lf0G

5lf0h

PDB Chain 5lf0h

5lf0H

PDB Chain 5lf0H

5lf0I

PDB Chain 5lf0I

5lf0J

PDB Chain 5lf0J

5lf0K

PDB Chain 5lf0K

5lf0L

PDB Chain 5lf0L

5lf0M

PDB Chain 5lf0M

5lf0N

PDB Chain 5lf0N

5lf0O

PDB Chain 5lf0O

5lf0P

PDB Chain 5lf0P

5lf0Q

PDB Chain 5lf0Q

5lf0R

PDB Chain 5lf0R

5lf0S

PDB Chain 5lf0S

5lf0T

PDB Chain 5lf0T

5lf0U

PDB Chain 5lf0U

5lf0V

PDB Chain 5lf0V

5lf0W

PDB Chain 5lf0W

5lf0X

PDB Chain 5lf0X

5lf0Y

PDB Chain 5lf0Y

5lf0Z

PDB Chain 5lf0Z

5lf0a00

CATH Domain 5lf0a00

5lf0A00

CATH Domain 5lf0A00

5lf0b00

CATH Domain 5lf0b00

5lf0B00

CATH Domain 5lf0B00

5lf0C00

CATH Domain 5lf0C00

5lf0D00

CATH Domain 5lf0D00

5lf0E00

CATH Domain 5lf0E00

5lf0F00

CATH Domain 5lf0F00

5lf0G00

CATH Domain 5lf0G00

5lf0H00

CATH Domain 5lf0H00

5lf0I00

CATH Domain 5lf0I00

5lf0J00

CATH Domain 5lf0J00

5lf0K00

CATH Domain 5lf0K00

5lf0L00

CATH Domain 5lf0L00

5lf0M00

CATH Domain 5lf0M00

5lf0N00

CATH Domain 5lf0N00

5lf0O00

CATH Domain 5lf0O00

5lf0P00

CATH Domain 5lf0P00

5lf0Q00

CATH Domain 5lf0Q00

5lf0R00

CATH Domain 5lf0R00

5lf0S00

CATH Domain 5lf0S00

5lf0T00

CATH Domain 5lf0T00

5lf0U00

CATH Domain 5lf0U00

5lf0V00

CATH Domain 5lf0V00

5lf0W00

CATH Domain 5lf0W00

5lf0X00

CATH Domain 5lf0X00

5lf0Y00

CATH Domain 5lf0Y00

5lf0Z00

CATH Domain 5lf0Z00

PDB Prints

PDB Chains (34)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
c	05 Sep, 2016	Rejected
C	05 Sep, 2016	Chopped
d	05 Sep, 2016	Rejected
D	05 Sep, 2016	Chopped
e	05 Sep, 2016	Rejected
E	05 Sep, 2016	Chopped
f	05 Sep, 2016	Rejected
F	05 Sep, 2016	Chopped
g	05 Sep, 2016	Rejected
G	05 Sep, 2016	Chopped
h	05 Sep, 2016	Rejected
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lf0a00	09 Sep, 2016	3.60.20.10	Assigned
5lf0A00	09 Sep, 2016	3.60.20.10	Assigned
5lf0b00	20 Oct, 2016	3.60.20.10	Assigned
5lf0B00	09 Sep, 2016	3.60.20.10	Assigned
5lf0C00	09 Sep, 2016	3.60.20.10	Assigned
5lf0D00	09 Sep, 2016	3.60.20.10	Assigned
5lf0E00	09 Sep, 2016	3.60.20.10	Assigned
5lf0F00	09 Sep, 2016	3.60.20.10	Assigned
5lf0G00	09 Sep, 2016	3.60.20.10	Assigned
5lf0H00	09 Sep, 2016	3.60.20.10	Assigned
5lf0I00	09 Sep, 2016	3.60.20.10	Assigned
5lf0J00	09 Sep, 2016	3.60.20.10	Assigned
5lf0K00	09 Sep, 2016	3.60.20.10	Assigned
5lf0L00	09 Sep, 2016	3.60.20.10	Assigned
5lf0M00	09 Sep, 2016	3.60.20.10	Assigned
5lf0N00	20 Oct, 2016	3.60.20.10	Assigned
5lf0O00	09 Sep, 2016	3.60.20.10	Assigned
5lf0P00	09 Sep, 2016	3.60.20.10	Assigned
5lf0Q00	09 Sep, 2016	3.60.20.10	Assigned
5lf0R00	09 Sep, 2016	3.60.20.10	Assigned
5lf0S00	09 Sep, 2016	3.60.20.10	Assigned
5lf0T00	09 Sep, 2016	3.60.20.10	Assigned
5lf0U00	09 Sep, 2016	3.60.20.10	Assigned
5lf0V00	09 Sep, 2016	3.60.20.10	Assigned
5lf0W00	09 Sep, 2016	3.60.20.10	Assigned
5lf0X00	09 Sep, 2016	3.60.20.10	Assigned
5lf0Y00	09 Sep, 2016	3.60.20.10	Assigned
5lf0Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1