PDB 5le5

PDB Links
Overview

PDB Information

PDB	5LE5
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. Science
Header	Hydrolase
Released	2016-06-29
Resolution	1.800
CATH Insert Date	04 Sep, 2016

PDB Images (57)

5le5

PDB 5le5

5le5a

PDB Chain 5le5a

5le5A

PDB Chain 5le5A

5le5b

PDB Chain 5le5b

5le5B

PDB Chain 5le5B

5le5C

PDB Chain 5le5C

5le5D

PDB Chain 5le5D

5le5E

PDB Chain 5le5E

5le5F

PDB Chain 5le5F

5le5G

PDB Chain 5le5G

5le5H

PDB Chain 5le5H

5le5I

PDB Chain 5le5I

5le5J

PDB Chain 5le5J

5le5K

PDB Chain 5le5K

5le5L

PDB Chain 5le5L

5le5M

PDB Chain 5le5M

5le5N

PDB Chain 5le5N

5le5O

PDB Chain 5le5O

5le5P

PDB Chain 5le5P

5le5Q

PDB Chain 5le5Q

5le5R

PDB Chain 5le5R

5le5S

PDB Chain 5le5S

5le5T

PDB Chain 5le5T

5le5U

PDB Chain 5le5U

5le5V

PDB Chain 5le5V

5le5W

PDB Chain 5le5W

5le5X

PDB Chain 5le5X

5le5Y

PDB Chain 5le5Y

5le5Z

PDB Chain 5le5Z

5le5a00

CATH Domain 5le5a00

5le5A00

CATH Domain 5le5A00

5le5b00

CATH Domain 5le5b00

5le5B00

CATH Domain 5le5B00

5le5C00

CATH Domain 5le5C00

5le5D00

CATH Domain 5le5D00

5le5E00

CATH Domain 5le5E00

5le5F00

CATH Domain 5le5F00

5le5G00

CATH Domain 5le5G00

5le5H00

CATH Domain 5le5H00

5le5I00

CATH Domain 5le5I00

5le5J00

CATH Domain 5le5J00

5le5K00

CATH Domain 5le5K00

5le5L00

CATH Domain 5le5L00

5le5M00

CATH Domain 5le5M00

5le5N00

CATH Domain 5le5N00

5le5O00

CATH Domain 5le5O00

5le5P00

CATH Domain 5le5P00

5le5Q00

CATH Domain 5le5Q00

5le5R00

CATH Domain 5le5R00

5le5S00

CATH Domain 5le5S00

5le5T00

CATH Domain 5le5T00

5le5U00

CATH Domain 5le5U00

5le5V00

CATH Domain 5le5V00

5le5W00

CATH Domain 5le5W00

5le5X00

CATH Domain 5le5X00

5le5Y00

CATH Domain 5le5Y00

5le5Z00

CATH Domain 5le5Z00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	05 Sep, 2016	Chopped
A	05 Sep, 2016	Chopped
b	05 Sep, 2016	Chopped
B	05 Sep, 2016	Chopped
C	05 Sep, 2016	Chopped
D	05 Sep, 2016	Chopped
E	05 Sep, 2016	Chopped
F	05 Sep, 2016	Chopped
G	05 Sep, 2016	Chopped
H	05 Sep, 2016	Chopped
I	05 Sep, 2016	Chopped
J	05 Sep, 2016	Chopped
K	05 Sep, 2016	Chopped
L	05 Sep, 2016	Chopped
M	05 Sep, 2016	Chopped
N	05 Sep, 2016	Chopped
O	05 Sep, 2016	Chopped
P	05 Sep, 2016	Chopped
Q	05 Sep, 2016	Chopped
R	05 Sep, 2016	Chopped
S	05 Sep, 2016	Chopped
T	05 Sep, 2016	Chopped
U	05 Sep, 2016	Chopped
V	05 Sep, 2016	Chopped
W	05 Sep, 2016	Chopped
X	05 Sep, 2016	Chopped
Y	05 Sep, 2016	Chopped
Z	05 Sep, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5le5a00	09 Sep, 2016	3.60.20.10	Assigned
5le5A00	09 Sep, 2016	3.60.20.10	Assigned
5le5b00	20 Oct, 2016	3.60.20.10	Assigned
5le5B00	09 Sep, 2016	3.60.20.10	Assigned
5le5C00	09 Sep, 2016	3.60.20.10	Assigned
5le5D00	08 Sep, 2016	3.60.20.10	Assigned
5le5E00	08 Sep, 2016	3.60.20.10	Assigned
5le5F00	08 Sep, 2016	3.60.20.10	Assigned
5le5G00	09 Sep, 2016	3.60.20.10	Assigned
5le5H00	09 Sep, 2016	3.60.20.10	Assigned
5le5I00	09 Sep, 2016	3.60.20.10	Assigned
5le5J00	09 Sep, 2016	3.60.20.10	Assigned
5le5K00	09 Sep, 2016	3.60.20.10	Assigned
5le5L00	08 Sep, 2016	3.60.20.10	Assigned
5le5M00	08 Sep, 2016	3.60.20.10	Assigned
5le5N00	20 Oct, 2016	3.60.20.10	Assigned
5le5O00	08 Sep, 2016	3.60.20.10	Assigned
5le5P00	09 Sep, 2016	3.60.20.10	Assigned
5le5Q00	09 Sep, 2016	3.60.20.10	Assigned
5le5R00	09 Sep, 2016	3.60.20.10	Assigned
5le5S00	09 Sep, 2016	3.60.20.10	Assigned
5le5T00	09 Sep, 2016	3.60.20.10	Assigned
5le5U00	09 Sep, 2016	3.60.20.10	Assigned
5le5V00	08 Sep, 2016	3.60.20.10	Assigned
5le5W00	08 Sep, 2016	3.60.20.10	Assigned
5le5X00	08 Sep, 2016	3.60.20.10	Assigned
5le5Y00	08 Sep, 2016	3.60.20.10	Assigned
5le5Z00	09 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P25786	PSA1_HUMAN	Homo sapiens	Proteasome subunit alpha type-1
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
P25787	PSA2_HUMAN	Homo sapiens	Proteasome subunit alpha type-2
P28066	PSA5_HUMAN	Homo sapiens	Proteasome subunit alpha type-5
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P28072	PSB6_HUMAN	Homo sapiens	Proteasome subunit beta type-6
P28070	PSB4_HUMAN	Homo sapiens	Proteasome subunit beta type-4
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
O14818	PSA7_HUMAN	Homo sapiens	Proteasome subunit alpha type-7
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P20618	PSB1_HUMAN	Homo sapiens	Proteasome subunit beta type-1
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
P25788	PSA3_HUMAN	Homo sapiens	Proteasome subunit alpha type-3
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P49721	PSB2_HUMAN	Homo sapiens	Proteasome subunit beta type-2
P28074	PSB5_HUMAN	Homo sapiens	Proteasome subunit beta type-5
P60900	PSA6_HUMAN	Homo sapiens	Proteasome subunit alpha type-6
P25789	PSA4_HUMAN	Homo sapiens	Proteasome subunit alpha type-4
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P49720	PSB3_HUMAN	Homo sapiens	Proteasome subunit beta type-3