PDB 5jhr

PDB Links
Overview

PDB Information

PDB	5JHR
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Structure-Based Design of beta 5c Selective Inhibitors of Human Constitutive Proteasomes. Xin, B.T., de Bruin, G., Huber, E.M., Besse, A., Florea, B.I., Filippov, D.V., van der Marel, G.A., Kisselev, A.F., van der Stelt, M., Driessen, C., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2016-04-21
Resolution	2.900
CATH Insert Date	14 Aug, 2016

PDB Images (57)

5jhr

PDB 5jhr

5jhra

PDB Chain 5jhra

5jhrA

PDB Chain 5jhrA

5jhrb

PDB Chain 5jhrb

5jhrB

PDB Chain 5jhrB

5jhrC

PDB Chain 5jhrC

5jhrD

PDB Chain 5jhrD

5jhrE

PDB Chain 5jhrE

5jhrF

PDB Chain 5jhrF

5jhrG

PDB Chain 5jhrG

5jhrH

PDB Chain 5jhrH

5jhrI

PDB Chain 5jhrI

5jhrJ

PDB Chain 5jhrJ

5jhrK

PDB Chain 5jhrK

5jhrL

PDB Chain 5jhrL

5jhrM

PDB Chain 5jhrM

5jhrN

PDB Chain 5jhrN

5jhrO

PDB Chain 5jhrO

5jhrP

PDB Chain 5jhrP

5jhrQ

PDB Chain 5jhrQ

5jhrR

PDB Chain 5jhrR

5jhrS

PDB Chain 5jhrS

5jhrT

PDB Chain 5jhrT

5jhrU

PDB Chain 5jhrU

5jhrV

PDB Chain 5jhrV

5jhrW

PDB Chain 5jhrW

5jhrX

PDB Chain 5jhrX

5jhrY

PDB Chain 5jhrY

5jhrZ

PDB Chain 5jhrZ

5jhra00

CATH Domain 5jhra00

5jhrA00

CATH Domain 5jhrA00

5jhrb00

CATH Domain 5jhrb00

5jhrB00

CATH Domain 5jhrB00

5jhrC00

CATH Domain 5jhrC00

5jhrD00

CATH Domain 5jhrD00

5jhrE00

CATH Domain 5jhrE00

5jhrF00

CATH Domain 5jhrF00

5jhrG00

CATH Domain 5jhrG00

5jhrH00

CATH Domain 5jhrH00

5jhrI00

CATH Domain 5jhrI00

5jhrJ00

CATH Domain 5jhrJ00

5jhrK00

CATH Domain 5jhrK00

5jhrL00

CATH Domain 5jhrL00

5jhrM00

CATH Domain 5jhrM00

5jhrN00

CATH Domain 5jhrN00

5jhrO00

CATH Domain 5jhrO00

5jhrP00

CATH Domain 5jhrP00

5jhrQ00

CATH Domain 5jhrQ00

5jhrR00

CATH Domain 5jhrR00

5jhrS00

CATH Domain 5jhrS00

5jhrT00

CATH Domain 5jhrT00

5jhrU00

CATH Domain 5jhrU00

5jhrV00

CATH Domain 5jhrV00

5jhrW00

CATH Domain 5jhrW00

5jhrX00

CATH Domain 5jhrX00

5jhrY00

CATH Domain 5jhrY00

5jhrZ00

CATH Domain 5jhrZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	15 Aug, 2016	Chopped
A	15 Aug, 2016	Chopped
b	15 Aug, 2016	Chopped
B	15 Aug, 2016	Chopped
C	15 Aug, 2016	Chopped
D	15 Aug, 2016	Chopped
E	15 Aug, 2016	Chopped
F	15 Aug, 2016	Chopped
G	15 Aug, 2016	Chopped
H	15 Aug, 2016	Chopped
I	15 Aug, 2016	Chopped
J	15 Aug, 2016	Chopped
K	15 Aug, 2016	Chopped
L	15 Aug, 2016	Chopped
M	15 Aug, 2016	Chopped
N	15 Aug, 2016	Chopped
O	15 Aug, 2016	Chopped
P	15 Aug, 2016	Chopped
Q	15 Aug, 2016	Chopped
R	15 Aug, 2016	Chopped
S	15 Aug, 2016	Chopped
T	15 Aug, 2016	Chopped
U	15 Aug, 2016	Chopped
V	15 Aug, 2016	Chopped
W	15 Aug, 2016	Chopped
X	15 Aug, 2016	Chopped
Y	15 Aug, 2016	Chopped
Z	15 Aug, 2016	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5jhra00	01 Sep, 2016	3.60.20.10	Assigned
5jhrA00	01 Sep, 2016	3.60.20.10	Assigned
5jhrb00	20 Oct, 2016	3.60.20.10	Assigned
5jhrB00	01 Sep, 2016	3.60.20.10	Assigned
5jhrC00	01 Sep, 2016	3.60.20.10	Assigned
5jhrD00	01 Sep, 2016	3.60.20.10	Assigned
5jhrE00	01 Sep, 2016	3.60.20.10	Assigned
5jhrF00	01 Sep, 2016	3.60.20.10	Assigned
5jhrG00	01 Sep, 2016	3.60.20.10	Assigned
5jhrH00	01 Sep, 2016	3.60.20.10	Assigned
5jhrI00	01 Sep, 2016	3.60.20.10	Assigned
5jhrJ00	01 Sep, 2016	3.60.20.10	Assigned
5jhrK00	01 Sep, 2016	3.60.20.10	Assigned
5jhrL00	01 Sep, 2016	3.60.20.10	Assigned
5jhrM00	01 Sep, 2016	3.60.20.10	Assigned
5jhrN00	20 Oct, 2016	3.60.20.10	Assigned
5jhrO00	01 Sep, 2016	3.60.20.10	Assigned
5jhrP00	01 Sep, 2016	3.60.20.10	Assigned
5jhrQ00	01 Sep, 2016	3.60.20.10	Assigned
5jhrR00	01 Sep, 2016	3.60.20.10	Assigned
5jhrS00	01 Sep, 2016	3.60.20.10	Assigned
5jhrT00	01 Sep, 2016	3.60.20.10	Assigned
5jhrU00	01 Sep, 2016	3.60.20.10	Assigned
5jhrV00	01 Sep, 2016	3.60.20.10	Assigned
5jhrW00	01 Sep, 2016	3.60.20.10	Assigned
5jhrX00	01 Sep, 2016	3.60.20.10	Assigned
5jhrY00	01 Sep, 2016	3.60.20.10	Assigned
5jhrZ00	01 Sep, 2016	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1