PDB 5j79

PDB Information

PDB5J79
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
Haile, P.A., Votta, B.J., Marquis, R.W., Bury, M.J., Mehlmann, J.F., Singhaus, R., Charnley, A.K., Lakdawala, A.S., Convery, M.A., Lipshutz, D.B., Desai, B.M., Swift, B., Capriotti, C.A., Berger, S.B., Mahajan, M.K., Reilly, M.A., Rivera, E.J., Sun, H.H., Nagilla, R., Beal, A.M., Finger, J.N., Cook, M.N., King, B.W., Ouellette, M.T., Totoritis, R.D., Pierdomenico, M., Negroni, A., Stronati, L., Cucchiara, S., Ziokowski, B., Vossenkamper, A., MacDonald, T.T., Gough, P.J., Bertin, J., Casillas, L.N.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-04-06
Resolution2.690
CATH Insert Date29 May, 2016

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 30 May, 2016 Chopped
B 30 May, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5j79A00 19 Jul, 2016 1.10.510.10 Assigned
5j79B00 19 Jul, 2016 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2