PDB 5hx6

PDB Information

PDB5HX6
MethodX-RAY DIFFRACTION
Host OrganismBaculovirus expression vector pFastBac1-HM
Gene SourceHomo sapiens
Primary Citation
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Harris, P.A., King, B.W., Bandyopadhyay, D., Berger, S.B., Campobasso, N., Capriotti, C.A., Cox, J.A., Dare, L., Dong, X., Finger, J.N., Grady, L.C., Hoffman, S.J., Jeong, J.U., Kang, J., Kasparcova, V., Lakdawala, A.S., Lehr, R., McNulty, D.E., Nagilla, R., Ouellette, M.T., Pao, C.S., Rendina, A.R., Schaeffer, M.C., Summerfield, J.D., Swift, B.A., Totoritis, R.D., Ward, P., Zhang, A., Zhang, D., Marquis, R.W., Bertin, J., Gough, P.J.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-01-29
Resolution2.230
CATH Insert Date10 Apr, 2016

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5hx6A01 15 May, 2016 3.30.200.20 Assigned
5hx6A02 15 May, 2016 1.10.510.10 Assigned
5hx6B01 14 May, 2016 3.30.200.20 Assigned
5hx6B02 14 May, 2016 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q13546 RIPK1_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 1
Q13546 RIPK1_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 1