PDB Information

PDB5FA5
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Mavrakis, K.J., McDonald, E.R., Schlabach, M.R., Billy, E., Hoffman, G.R., deWeck, A., Ruddy, D.A., Venkatesan, K., Yu, J., McAllister, G., Stump, M., deBeaumont, R., Ho, S., Yue, Y., Liu, Y., Yan-Neale, Y., Yang, G., Lin, F., Yin, H., Gao, H., Kipp, D.R., Zhao, S., McNamara, J.T., Sprague, E.R., Zheng, B., Lin, Y., Cho, Y.S., Gu, J., Crawford, K., Ciccone, D., Vitari, A.C., Lai, A., Capka, V., Hurov, K., Porter, J.A., Tallarico, J., Mickanin, C., Lees, E., Pagliarini, R., Keen, N., Schmelzle, T., Hofmann, F., Stegmeier, F., Sellers, W.R.
Science
HeaderTransferase/Protein Binding
Released2015-12-10
Resolution2.340
CATH Insert Date10 Apr, 2016

PDB Images (8)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped
C 11 Apr, 2016 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5fa5A01 10 May, 2016 3.20.20.150 Assigned
5fa5A02 10 May, 2016 3.40.50.150 Assigned
5fa5A03 10 May, 2016 2.70.160.11 Assigned
5fa5B00 10 May, 2016 2.130.10.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q9BQA1 MEP50_HUMAN Homo sapiens Methylosome protein 50
O14744 ANM5_HUMAN Homo sapiens Protein arginine N-methyltransferase 5
P62805 H4_HUMAN Homo sapiens Histone H4