PDB 5enk

PDB Information

PDB5ENK
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain A beta Reduction in Rodents.
Wu, Y.J., Guernon, J., Yang, F., Snyder, L., Shi, J., Mcclure, A., Rajamani, R., Park, H., Ng, A., Lewis, H., Chang, C., Camac, D., Toyn, J.H., Ahlijanian, M.K., Albright, C.F., Macor, J.E., Thompson, L.A.
Acs Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-11-09
Resolution2.110
CATH Insert Date17 Jul, 2016

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 18 Jul, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5enkA01 01 Sep, 2016 2.40.70.10 Assigned
5enkA02 01 Sep, 2016 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1