PDB 5dxh

PDB Information

PDB5DXH
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
Heffron, T.P., Heald, R.A., Ndubaku, C., Wei, B., Augistin, M., Do, S., Edgar, K., Eigenbrot, C., Friedman, L., Gancia, E., Jackson, P.S., Jones, G., Kolesnikov, A., Lee, L.B., Lesnick, J.D., Lewis, C., McLean, N., Mortl, M., Nonomiya, J., Pang, J., Price, S., Prior, W.W., Salphati, L., Sideris, S., Staben, S.T., Steinbacher, S., Tsui, V., Wallin, J., Sampath, D., Olivero, A.G.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2015-09-23
Resolution3.000
CATH Insert Date10 Apr, 2016

PDB Images (16)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped
D 11 Apr, 2016 Chopped
E 11 Apr, 2016 Domchop review

CATH Domains (11)

Domain ID Date inserted into CATH Superfamily CATH Status
5dxhA01 12 Jul, 2018 3.10.20.770 Assigned
5dxhA02 12 Jul, 2018 2.60.40.150 Assigned
5dxhA03 12 Jul, 2018 1.25.40.70 Assigned
5dxhA04 12 Jul, 2018 3.30.1010.10 Assigned
5dxhA05 12 Jul, 2018 1.10.1070.11 Assigned
5dxhB00 01 Dec, 2017 1.10.287.1490 Assigned
5dxhD01 12 Jul, 2018 3.10.20.770 Assigned
5dxhD02 12 Jul, 2018 2.60.40.150 Assigned
5dxhD03 12 Jul, 2018 1.25.40.70 Assigned
5dxhD04 12 Jul, 2018 3.30.1010.10 Assigned
5dxhD05 12 Jul, 2018 1.10.1070.11 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P42336 PK3CA_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
P23727 P85A_BOVIN Bos taurus Phosphatidylinositol 3-kinase regulatory subunit alpha
P23727 P85A_BOVIN Bos taurus Phosphatidylinositol 3-kinase regulatory subunit alpha
P42336 PK3CA_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform