Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.
Burger, M.T., Nishiguchi, G., Han, W., Lan, J., Simmons, R., Atallah, G., Ding, Y., Tamez, V., Zhang, Y., Mathur, M., Muller, K., Bellamacina, C., Lindvall, M.K., Zang, R., Huh, K., Feucht, P., Zavorotinskaya, T., Dai, Y., Basham, S., Chan, J., Ginn, E., Aycinena, A., Holash, J., Castillo, J., Langowski, J.L., Wang, Y., Chen, M.Y., Lambert, A., Fritsch, C., Kauffmann, A., Pfister, E., Vanasse, K.G., Garcia, P.D.
J.Med.Chem.
