PDB 5cf8

PDB Information

PDB5CF8
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
Wan, H., Schroeder, G.M., Hart, A.C., Inghrim, J., Grebinski, J., Tokarski, J.S., Lorenzi, M.V., You, D., Mcdevitt, T., Penhallow, B., Vuppugalla, R., Zhang, Y., Gu, X., Iyer, R., Lombardo, L.J., Trainor, G.L., Ruepp, S., Lippy, J., Blat, Y., Sack, J.S., Khan, J.A., Stefanski, K., Sleczka, B., Mathur, A., Sun, J.H., Wong, M.K., Wu, D.R., Li, P., Gupta, A., Arunachalam, P.N., Pragalathan, B., Narayanan, S., K C, N., Kuppusamy, P., Purandare, A.V.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-07-08
Resolution1.800
CATH Insert Date06 Sep, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 07 Sep, 2015 Chopped
B 07 Sep, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5cf8A01 30 Sep, 2015 3.30.200.20 Assigned
5cf8A02 30 Sep, 2015 1.10.510.10 Assigned
5cf8B01 30 Sep, 2015 3.30.200.20 Assigned
5cf8B02 30 Sep, 2015 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2
O60674 JAK2_HUMAN Homo sapiens Tyrosine-protein kinase JAK2