PDB 5c2a

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Overview

PDB Information

PDB	5C2A
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis. Shipe, W.D., Sharik, S.S., Barrow, J.C., McGaughey, G.B., Theberge, C.R., Uslaner, J.M., Yan, Y., Renger, J.J., Smith, S.M., Coleman, P.J., Cox, C.D. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2015-06-15
Resolution	2.000
CATH Insert Date	04 Oct, 2015

PDB Images (5)

Image of CATH 5c2a

5c2a

PDB 5c2a

Image of CATH 5c2aA

5c2aA

PDB Chain 5c2aA

Image of CATH 5c2aB

5c2aB

PDB Chain 5c2aB

Image of CATH 5c2aA00

5c2aA00

CATH Domain 5c2aA00

Image of CATH 5c2aB00

5c2aB00

CATH Domain 5c2aB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	05 Oct, 2015	Chopped
B	05 Oct, 2015	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5c2aA00	01 Nov, 2015	1.10.1300.10	Assigned
5c2aB00	01 Nov, 2015	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A