PDB Information

PDB5BOO
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourcePlasmodium falciparum (isolate 3D7)
Primary Citation
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Phillips, M.A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K.L., Njoroge, J.W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D.R., Deng, X., Laird, T., Bhatia, S.N., March, S., Ng, C.L., Fidock, D.A., Wittlin, S., Lafuente-Monasterio, M., Benito, F.J., Alonso, L.M., Martinez, M.S., Jimenez-Diaz, M.B., Bazaga, S.F., Angulo-Barturen, I., Haselden, J.N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A.M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V.M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K.S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., Rogers, M.J., Rathod, P.K., Burrows, J.N., Charman, S.A.
Sci Transl Med
HeaderOxidoreductase/Inhibitor
Released2015-05-27
Resolution2.800
CATH Insert Date16 Aug, 2015

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 17 Aug, 2015 Chopped
B 17 Aug, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5booA00 24 Aug, 2015 3.20.20.70 Assigned
5booB00 24 Aug, 2015 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q08210 PYRD_PLAF7 Plasmodium falciparum 3D7 Dihydroorotate dehydrogenase (quinone), mitochondrial
Q08210 PYRD_PLAF7 Plasmodium falciparum 3D7 Dihydroorotate dehydrogenase (quinone), mitochondrial
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