PDB 4zyf

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

PDB Links
Overview

PDB Information

PDB	4ZYF
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. Holzer, P., Masuya, K., Furet, P., Kallen, J., Valat-Stachyra, T., Ferretti, S., Berghausen, J., Bouisset-Leonard, M., Buschmann, N., Pissot-Soldermann, C., Rynn, C., Ruetz, S., Stutz, S., Chene, P., Jeay, S., Gessier, F. J.Med.Chem.
Header	Cell Cycle
Released	2015-05-21
Resolution	1.800
CATH Insert Date	16 Aug, 2015

PDB Images (3)

Image of CATH 4zyf

4zyf

PDB 4zyf

Image of CATH 4zyfA

4zyfA

PDB Chain 4zyfA

Image of CATH 4zyfA00

4zyfA00

CATH Domain 4zyfA00

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	17 Aug, 2015	Chopped

CATH Domains (1)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4zyfA00	20 Mar, 2016	1.10.245.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
Q00987	MDM2_HUMAN	Homo sapiens	E3 ubiquitin-protein ligase Mdm2