Methyl-substitution of an iminohydantoin spiropiperidine beta-secretase (BACE-1) inhibitor has a profound effect on its potency.
Egbertson, M., McGaughey, G.B., Pitzenberger, S.M., Stauffer, S.R., Coburn, C.A., Stachel, S.J., Yang, W., Barrow, J.C., Neilson, L.A., McWherter, M., Perlow, D., Fahr, B., Munshi, S., Allison, T.J., Holloway, K., Selnick, H.G., Yang, Z., Swestock, J., Simon, A.J., Sankaranarayanan, S., Colussi, D., Tugusheva, K., Lai, M.T., Pietrak, B., Haugabook, S., Jin, L., Chen, I.W., Holahan, M., Stranieri-Michener, M., Cook, J.J., Vacca, J., Graham, S.L.
Bioorg.Med.Chem.Lett.