PDB 4zlo

PDB Links
Overview

PDB Information

PDB	4ZLO
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. Karpov, A.S., Amiri, P., Bellamacina, C., Bellance, M.H., Breitenstein, W., Daniel, D., Denay, R., Fabbro, D., Fernandez, C., Galuba, I., Guerro-Lagasse, S., Gutmann, S., Hinh, L., Jahnke, W., Klopp, J., Lai, A., Lindvall, M.K., Ma, S., Mobitz, H., Pecchi, S., Rummel, G., Shoemaker, K., Trappe, J., Voliva, C., Cowan-Jacob, S.W., Marzinzik, A.L. Acs Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2015-05-01
Resolution	2.500
CATH Insert Date	16 Aug, 2015

PDB Images (7)

Image of CATH 4zlo

4zlo

PDB 4zlo

Image of CATH 4zloA

4zloA

PDB Chain 4zloA

Image of CATH 4zloB

4zloB

PDB Chain 4zloB

Image of CATH 4zloA01

4zloA01

CATH Domain 4zloA01

Image of CATH 4zloA02

4zloA02

CATH Domain 4zloA02

Image of CATH 4zloB01

4zloB01

CATH Domain 4zloB01

Image of CATH 4zloB02

4zloB02

CATH Domain 4zloB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	17 Aug, 2015	Chopped
B	17 Aug, 2015	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4zloA01	24 Aug, 2015	3.30.200.20	Assigned
4zloA02	24 Aug, 2015	1.10.510.10	Assigned
4zloB01	24 Aug, 2015	3.30.200.20	Assigned
4zloB02	24 Aug, 2015	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q13153	PAK1_HUMAN	Homo sapiens	Serine/threonine-protein kinase PAK 1
Q13153	PAK1_HUMAN	Homo sapiens	Serine/threonine-protein kinase PAK 1