PDB 4zji

PDB Information

PDB4ZJI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.
Karpov, A.S., Amiri, P., Bellamacina, C., Bellance, M.H., Breitenstein, W., Daniel, D., Denay, R., Fabbro, D., Fernandez, C., Galuba, I., Guerro-Lagasse, S., Gutmann, S., Hinh, L., Jahnke, W., Klopp, J., Lai, A., Lindvall, M.K., Ma, S., Mobitz, H., Pecchi, S., Rummel, G., Shoemaker, K., Trappe, J., Voliva, C., Cowan-Jacob, S.W., Marzinzik, A.L.
Acs Med.Chem.Lett.
HeaderTransferase
Released2015-04-29
Resolution1.990
CATH Insert Date28 Jun, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4zjiA01 27 Jul, 2015 3.30.200.20 Assigned
4zjiA02 27 Jul, 2015 1.10.510.10 Assigned
4zjiB01 27 Jul, 2015 3.30.200.20 Assigned
4zjiB02 27 Jul, 2015 1.10.510.10 Assigned
4zjiC01 27 Jul, 2015 3.30.200.20 Assigned
4zjiC02 27 Jul, 2015 1.10.510.10 Assigned
4zjiD01 27 Jul, 2015 3.30.200.20 Assigned
4zjiD02 27 Jul, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1