PDB 4zbf

PDB Information

PDB4ZBF
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., Rossanese, O.W., Lee, T., Olejniczak, E.T., Fesik, S.W.
J.Med.Chem.
HeaderApoptosis/Apoptosis Inhibitor
Released2015-04-14
Resolution2.200
CATH Insert Date28 Jun, 2015

PDB Images (25)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped
E 29 Jun, 2015 Chopped
F 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
H 29 Jun, 2015 Chopped
I 29 Jun, 2015 Chopped
J 29 Jun, 2015 Chopped
K 29 Jun, 2015 Chopped
L 29 Jun, 2015 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
4zbfA01 27 Jul, 2015 1.10.437.10 Assigned
4zbfB01 27 Jul, 2015 1.10.437.10 Assigned
4zbfC01 27 Jul, 2015 1.10.437.10 Assigned
4zbfD01 27 Jul, 2015 1.10.437.10 Assigned
4zbfE01 27 Jul, 2015 1.10.437.10 Assigned
4zbfF01 27 Jul, 2015 1.10.437.10 Assigned
4zbfG01 27 Jul, 2015 1.10.437.10 Assigned
4zbfH01 27 Jul, 2015 1.10.437.10 Assigned
4zbfI01 27 Jul, 2015 1.10.437.10 Assigned
4zbfJ01 27 Jul, 2015 1.10.437.10 Assigned
4zbfK01 27 Jul, 2015 1.10.437.10 Assigned
4zbfL01 27 Jul, 2015 1.10.437.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1