PDB 4yes

PDB Information

PDB4YES
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.
Chobanian, H.R., Pio, B., Guo, Y., Shen, H., Huffman, M.A., Madeira, M., Salituro, G., Terebetski, J.L., Ormes, J., Jochnowitz, N., Hoos, L., Zhou, Y., Lewis, D., Hawes, B., Mitnaul, L., O'Neill, K., Ellsworth, K., Wang, L., Biftu, T., Duffy, J.L.
Acs Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-02-24
Resolution1.500
CATH Insert Date28 Jun, 2015

PDB Images (6)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Rejected
B 29 Jun, 2015 Chopped
H 29 Jun, 2015 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4yesB01 22 Jul, 2015 2.40.10.10 Assigned
4yesB02 22 Jul, 2015 2.40.10.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P00734 THRB_HUMAN Homo sapiens Prothrombin
P01050 HIRV1_HIRME Hirudo medicinalis Hirudin variant-1
P00734 THRB_HUMAN Homo sapiens Prothrombin
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