PDB 4x63

PDB Links
Overview

PDB Information

PDB	4X63
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Chan-Penebre, E., Kuplast, K.G., Majer, C.R., Boriack-Sjodin, P.A., Wigle, T.J., Johnston, L.D., Rioux, N., Munchhof, M.J., Jin, L., Jacques, S.L., West, K.A., Lingaraj, T., Stickland, K., Ribich, S.A., Raimondi, A., Scott, M.P., Waters, N.J., Pollock, R.M., Smith, J.J., Barbash, O., Pappalardi, M., Ho, T.F., Nurse, K., Oza, K.P., Gallagher, K.T., Kruger, R., Moyer, M.P., Copeland, R.A., Chesworth, R., Duncan, K.W. Nat.Chem.Biol.
Header	Transferase/Transferase Inhibitor
Released	2014-12-06
Resolution	3.050
CATH Insert Date	28 Jun, 2015

PDB Images (7)

Image of CATH 4x63

4x63

PDB 4x63

Image of CATH 4x63A

4x63A

PDB Chain 4x63A

Image of CATH 4x63B

4x63B

PDB Chain 4x63B

Image of CATH 4x63A01

4x63A01

CATH Domain 4x63A01

Image of CATH 4x63A02

4x63A02

CATH Domain 4x63A02

Image of CATH 4x63A03

4x63A03

CATH Domain 4x63A03

Image of CATH 4x63B00

4x63B00

CATH Domain 4x63B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4x63A01	22 Jul, 2015	3.20.20.150	Assigned
4x63A02	22 Jul, 2015	3.40.50.150	Assigned
4x63A03	22 Jul, 2015	2.70.160.11	Assigned
4x63B00	22 Jul, 2015	2.130.10.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9BQA1	MEP50_HUMAN	Homo sapiens	Methylosome protein 50
O14744	ANM5_HUMAN	Homo sapiens	Protein arginine N-methyltransferase 5