PDB 4x61

PDB Links
Overview

PDB Information

PDB	4X61
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Chan-Penebre, E., Kuplast, K.G., Majer, C.R., Boriack-Sjodin, P.A., Wigle, T.J., Johnston, L.D., Rioux, N., Munchhof, M.J., Jin, L., Jacques, S.L., West, K.A., Lingaraj, T., Stickland, K., Ribich, S.A., Raimondi, A., Scott, M.P., Waters, N.J., Pollock, R.M., Smith, J.J., Barbash, O., Pappalardi, M., Ho, T.F., Nurse, K., Oza, K.P., Gallagher, K.T., Kruger, R., Moyer, M.P., Copeland, R.A., Chesworth, R., Duncan, K.W. Nat.Chem.Biol.
Header	Transferase/Transferase Inhibitor
Released	2014-12-06
Resolution	2.850
CATH Insert Date	28 Jun, 2015

PDB Images (7)

Image of CATH 4x61

4x61

PDB 4x61

Image of CATH 4x61A

4x61A

PDB Chain 4x61A

Image of CATH 4x61B

4x61B

PDB Chain 4x61B

Image of CATH 4x61A01

4x61A01

CATH Domain 4x61A01

Image of CATH 4x61A02

4x61A02

CATH Domain 4x61A02

Image of CATH 4x61A03

4x61A03

CATH Domain 4x61A03

Image of CATH 4x61B00

4x61B00

CATH Domain 4x61B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4x61A01	22 Jul, 2015	3.20.20.150	Assigned
4x61A02	22 Jul, 2015	3.40.50.150	Assigned
4x61A03	22 Jul, 2015	2.70.160.11	Assigned
4x61B00	20 Jul, 2015	2.130.10.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O14744	ANM5_HUMAN	Homo sapiens	Protein arginine N-methyltransferase 5
Q9BQA1	MEP50_HUMAN	Homo sapiens	Methylosome protein 50