PDB 4x60

PDB Links
Overview

PDB Information

PDB	4X60
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Chan-Penebre, E., Kuplast, K.G., Majer, C.R., Boriack-Sjodin, P.A., Wigle, T.J., Johnston, L.D., Rioux, N., Munchhof, M.J., Jin, L., Jacques, S.L., West, K.A., Lingaraj, T., Stickland, K., Ribich, S.A., Raimondi, A., Scott, M.P., Waters, N.J., Pollock, R.M., Smith, J.J., Barbash, O., Pappalardi, M., Ho, T.F., Nurse, K., Oza, K.P., Gallagher, K.T., Kruger, R., Moyer, M.P., Copeland, R.A., Chesworth, R., Duncan, K.W. Nat.Chem.Biol.
Header	Transferase/Transferase Inhibitor
Released	2014-12-06
Resolution	2.350
CATH Insert Date	28 Jun, 2015

PDB Images (7)

Image of CATH 4x60

4x60

PDB 4x60

Image of CATH 4x60A

4x60A

PDB Chain 4x60A

Image of CATH 4x60B

4x60B

PDB Chain 4x60B

Image of CATH 4x60A01

4x60A01

CATH Domain 4x60A01

Image of CATH 4x60A02

4x60A02

CATH Domain 4x60A02

Image of CATH 4x60A03

4x60A03

CATH Domain 4x60A03

Image of CATH 4x60B00

4x60B00

CATH Domain 4x60B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4x60A01	20 Jul, 2015	3.20.20.150	Assigned
4x60A02	20 Jul, 2015	3.40.50.150	Assigned
4x60A03	20 Jul, 2015	2.70.160.11	Assigned
4x60B00	22 Jul, 2015	2.130.10.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O14744	ANM5_HUMAN	Homo sapiens	Protein arginine N-methyltransferase 5
Q9BQA1	MEP50_HUMAN	Homo sapiens	Methylosome protein 50