PDB 4wtu

PDB Information

PDB4WTU
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
An Orally Available BACE1 Inhibitor That Affords Robust CNS A beta Reduction without Cardiovascular Liabilities.
Cheng, Y., Brown, J., Judd, T.C., Lopez, P., Qian, W., Powers, T.S., Chen, J.J., Bartberger, M.D., Chen, K., Dunn, R.T., Epstein, O., Fremeau, R.T., Harried, S., Hickman, D., Hitchcock, S.A., Luo, Y., Minatti, A.E., Patel, V.F., Vargas, H.M., Wahl, R.C., Weiss, M.M., Wen, P.H., White, R.D., Whittington, D.A., Zheng, X.M., Wood, S.
Acs Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-10-30
Resolution1.850
CATH Insert Date28 Jun, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4wtuA01 20 Jul, 2015 2.40.70.10 Assigned
4wtuA02 20 Jul, 2015 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
CATH-Gene3D is a Global Biodata Core Resource Learn more...