PDB 4wcu

PDB Links
Overview

PDB Information

PDB	4WCU
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis. Felding, J., Sorensen, M.D., Poulsen, T.D., Larsen, J., Andersson, C., Refer, P., Engell, K., Ladefoged, L.G., Thormann, T., Vinggaard, A.M., Hegardt, P., Sohoel, A., Nielsen, S.F. J. Med. Chem.
Header	Hydrolase
Released	2014-09-05
Resolution	2.350
CATH Insert Date	19 Oct, 2014

PDB Images (9)

Image of CATH 4wcu

4wcu

PDB 4wcu

Image of CATH 4wcuA

4wcuA

PDB Chain 4wcuA

Image of CATH 4wcuB

4wcuB

PDB Chain 4wcuB

Image of CATH 4wcuC

4wcuC

PDB Chain 4wcuC

Image of CATH 4wcuD

4wcuD

PDB Chain 4wcuD

Image of CATH 4wcuA00

4wcuA00

CATH Domain 4wcuA00

Image of CATH 4wcuB00

4wcuB00

CATH Domain 4wcuB00

Image of CATH 4wcuC00

4wcuC00

CATH Domain 4wcuC00

Image of CATH 4wcuD00

4wcuD00

CATH Domain 4wcuD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	20 Oct, 2014	Chopped
B	20 Oct, 2014	Chopped
C	20 Oct, 2014	Chopped
D	20 Oct, 2014	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4wcuA00	21 Oct, 2014	1.10.1300.10	Assigned
4wcuB00	21 Oct, 2014	1.10.1300.10	Assigned
4wcuC00	21 Oct, 2014	1.10.1300.10	Assigned
4wcuD00	21 Oct, 2014	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D