PDB 4w9l

PDB Information

PDB4W9L
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.200
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9lA00 16 Sep, 2014 3.10.20.90 Assigned
4w9lB00 16 Sep, 2014 3.30.710.10 Assigned
4w9lC01 17 Sep, 2014 2.60.40.780 Assigned
4w9lC02 17 Sep, 2014 1.10.750.10 Assigned
4w9lD00 17 Sep, 2014 3.10.20.90 Assigned
4w9lE00 17 Sep, 2014 3.30.710.10 Assigned
4w9lF01 17 Sep, 2014 2.60.40.780 Assigned
4w9lF02 17 Sep, 2014 1.10.750.10 Assigned
4w9lG00 16 Sep, 2014 3.10.20.90 Assigned
4w9lH00 16 Sep, 2014 3.30.710.10 Assigned
4w9lI01 16 Sep, 2014 2.60.40.780 Assigned
4w9lI02 16 Sep, 2014 1.10.750.10 Assigned
4w9lJ00 16 Sep, 2014 3.10.20.90 Assigned
4w9lK00 16 Sep, 2014 3.30.710.10 Assigned
4w9lL01 17 Sep, 2014 2.60.40.780 Assigned
4w9lL02 17 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor