PDB 4w9f
PDB Information
| PDB | 4W9F |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli BL21(DE3) |
| Gene Source | Homo sapiens |
| Primary Citation | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|
| Header | Ligase |
| Released | 2014-08-27 |
| Resolution | 2.100 |
| CATH Insert Date | 14 Sep, 2014 |
PDB Images (29)
4w9f
PDB 4w9f
4w9fA
PDB Chain 4w9fA
4w9fB
PDB Chain 4w9fB
4w9fC
PDB Chain 4w9fC
4w9fD
PDB Chain 4w9fD
4w9fE
PDB Chain 4w9fE
4w9fF
PDB Chain 4w9fF
4w9fG
PDB Chain 4w9fG
4w9fH
PDB Chain 4w9fH
4w9fI
PDB Chain 4w9fI
4w9fJ
PDB Chain 4w9fJ
4w9fK
PDB Chain 4w9fK
4w9fL
PDB Chain 4w9fL
4w9fA00
CATH Domain 4w9fA00
4w9fB00
CATH Domain 4w9fB00
4w9fC01
CATH Domain 4w9fC01
4w9fC02
CATH Domain 4w9fC02
4w9fD00
CATH Domain 4w9fD00
4w9fE00
CATH Domain 4w9fE00
4w9fF01
CATH Domain 4w9fF01
4w9fF02
CATH Domain 4w9fF02
4w9fG00
CATH Domain 4w9fG00
4w9fH00
CATH Domain 4w9fH00
4w9fI01
CATH Domain 4w9fI01
4w9fI02
CATH Domain 4w9fI02
4w9fJ00
CATH Domain 4w9fJ00
4w9fK00
CATH Domain 4w9fK00
4w9fL01
CATH Domain 4w9fL01
4w9fL02
CATH Domain 4w9fL02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 15 Sep, 2014 | Chopped |
| B | 15 Sep, 2014 | Chopped |
| C | 15 Sep, 2014 | Chopped |
| D | 15 Sep, 2014 | Chopped |
| E | 15 Sep, 2014 | Chopped |
| F | 15 Sep, 2014 | Chopped |
| G | 15 Sep, 2014 | Chopped |
| H | 15 Sep, 2014 | Chopped |
| I | 15 Sep, 2014 | Chopped |
| J | 15 Sep, 2014 | Chopped |
| K | 15 Sep, 2014 | Chopped |
| L | 15 Sep, 2014 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 4w9fA00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9fB00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9fC01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9fC02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9fD00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9fE00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9fF01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9fF02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9fG00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9fH00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9fI01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9fI02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9fJ00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9fK00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9fL01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9fL02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
