PDB 4w8e
PDB Information
PDB | 4W8E |
Method | X-RAY DIFFRACTION |
Host Organism | Escherichia coli |
Gene Source | Homo sapiens |
Primary Citation | Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J.Med.Chem.
|
Header | Transferase/Transferase Inhibitor |
Released | 2014-08-24 |
Resolution | 1.790 |
CATH Insert Date | 28 Jun, 2015 |
PDB Images (4)
PDB Prints
PDB Chains (1)
Chain ID | Date inserted into CATH | CATH Status |
---|---|---|
A | 29 Jun, 2015 | Chopped |
CATH Domains (2)
Domain ID | Date inserted into CATH | Superfamily | CATH Status |
---|---|---|---|
4w8eA01 | 15 Jul, 2015 | 3.30.200.20 | Assigned |
4w8eA02 | 15 Jul, 2015 | 1.10.510.10 | Assigned |
UniProtKB Entries (1)
Accession | Gene ID | Taxon | Description |
---|---|---|---|
Q9Y6E0 | STK24_HUMAN | Homo sapiens | Serine/threonine-protein kinase 24 |