Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
Brand, S., Norcross, N.R., Thompson, S., Harrison, J.R., Smith, V.C., Robinson, D.A., Torrie, L.S., McElroy, S.P., Hallyburton, I., Norval, S., Scullion, P., Stojanovski, L., Simeons, F.R., van Aalten, D., Frearson, J.A., Brenk, R., Fairlamb, A.H., Ferguson, M.A., Wyatt, P.G., Gilbert, I.H., Read, K.D.
J. Med. Chem.
