PDB 4u81

PDB Information

PDB4U81
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Robarge, K.D., Lee, W., Eigenbrot, C., Ultsch, M., Wiesmann, C., Heald, R., Price, S., Hewitt, J., Jackson, P., Savy, P., Burton, B., Choo, E.F., Pang, J., Boggs, J., Yang, A., Yang, X., Baumgardner, M.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2014-07-31
Resolution2.700
CATH Insert Date05 Oct, 2014

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 06 Oct, 2014 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4u81A01 08 Oct, 2014 3.30.200.20 Assigned
4u81A02 08 Oct, 2014 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q02750 MP2K1_HUMAN Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1
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