PDB Information

PDB4RX5
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Young, W.B., Barbosa, J., Blomgren, P., Bremer, M.C., Crawford, J.J., Dambach, D., Eigenbrot, C., Gallion, S., Johnson, A.R., Kropf, J.E., Lee, S.H., Liu, L., Lubach, J.W., Macaluso, J., Maciejewski, P., Mitchell, S.A., Ortwine, D.F., Di Paolo, J., Reif, K., Scheerens, H., Schmitt, A., Wang, X., Wong, H., Xiong, J.M., Xu, J., Yu, C., Zhao, Z., Currie, K.S.
Bioorg.Med.Chem.Lett.
HeaderTransferase
Released2014-12-08
Resolution1.360
CATH Insert Date20 Dec, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 21 Dec, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4rx5A01 05 Jan, 2016 3.30.200.20 Assigned
4rx5A02 05 Jan, 2016 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK
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