PDB 4rg0

PDB Information

PDB4RG0
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.
Lou, Y., Sweeney, Z.K., Kuglstatter, A., Davis, D., Goldstein, D.M., Han, X., Hong, J., Kocer, B., Kondru, R.K., Litman, R., McIntosh, J., Sarma, K., Suh, J., Taygerly, J., Owens, T.D.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2014-09-29
Resolution2.500
CATH Insert Date04 Jan, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Jan, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4rg0A01 10 Jan, 2015 3.30.200.20 Assigned
4rg0A02 10 Jan, 2015 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK
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