PDB 4q13

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Overview

PDB Information

PDB	4Q13
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. Fanning, S.W., Mayne, C.G., Dharmarajan, V., Carlson, K.E., Martin, T.A., Novick, S.J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B.S., Tajkhorshid, E., Griffin, P.R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J.A., Greene, G.L. Elife
Header	Hormone Binding Protein/Peptide
Released	2014-04-02
Resolution	2.240
CATH Insert Date	28 Jun, 2015

PDB Images (7)

Image of CATH 4q13

4q13

PDB 4q13

Image of CATH 4q13A

4q13A

PDB Chain 4q13A

Image of CATH 4q13B

4q13B

PDB Chain 4q13B

Image of CATH 4q13C

4q13C

PDB Chain 4q13C

Image of CATH 4q13D

4q13D

PDB Chain 4q13D

Image of CATH 4q13A00

4q13A00

CATH Domain 4q13A00

Image of CATH 4q13B00

4q13B00

CATH Domain 4q13B00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped
C	29 Jun, 2015	Rejected
D	29 Jun, 2015	Rejected

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4q13A00	10 Jul, 2015	1.10.565.10	Assigned
4q13B00	10 Jul, 2015	1.10.565.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q15596	NCOA2_HUMAN	Homo sapiens	Nuclear receptor coactivator 2
P03372	ESR1_HUMAN	Homo sapiens	Estrogen receptor
P03372	ESR1_HUMAN	Homo sapiens	Estrogen receptor
Q15596	NCOA2_HUMAN	Homo sapiens	Nuclear receptor coactivator 2