PDB 4opx

PDB Information

PDB4OPX
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
Patel, M.R., Bhatt, A., Steffen, J.D., Chergui, A., Murai, J., Pommier, Y., Pascal, J.M., Trombetta, L.D., Fronczek, F.R., Talele, T.T.
J.Med.Chem.
HeaderTransferase/Dna/Transferase Inhibitor
Released2014-02-06
Resolution3.310
CATH Insert Date20 Jul, 2014

PDB Images (17)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 21 Jul, 2014 Chopped
C 21 Jul, 2014 Chopped
D 21 Jul, 2014 Chopped
F 21 Jul, 2014 Chopped
M 21 Jul, 2014 Rejected
N 21 Jul, 2014 Rejected

CATH Domains (10)

Domain ID Date inserted into CATH Superfamily CATH Status
4opxA01 04 Jan, 2017 3.30.1740.10 Assigned
4opxA02 04 Jan, 2017 Holding pen
4opxC01 27 Jul, 2014 Holding pen
4opxC02 27 Jul, 2014 3.90.228.10 Assigned
4opxC03 27 Jul, 2014 1.20.142.10 Assigned
4opxD01 04 Jan, 2017 3.30.1740.10 Assigned
4opxD02 04 Jan, 2017 Cathedral cath submit
4opxF01 03 Aug, 2014 Holding pen
4opxF02 03 Aug, 2014 3.90.228.10 Assigned
4opxF03 03 Aug, 2014 1.20.142.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P09874 PARP1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase 1
P09874 PARP1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase 1
P09874 PARP1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase 1
P09874 PARP1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase 1