PDB Information

PDB4N1T
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad, H., Koolmeister, T., Jemth, A.S., Eshtad, S., Jacques, S.A., Strom, C.E., Svensson, L.M., Schultz, N., Lundback, T., Einarsdottir, B.O., Saleh, A., Gokturk, C., Baranczewski, P., Svensson, R., Berntsson, R.P., Gustafsson, R., Stromberg, K., Sanjiv, K., Jacques-Cordonnier, M.C., Desroses, M., Gustavsson, A.L., Olofsson, R., Johansson, F., Homan, E.J., Loseva, O., Brautigam, L., Johansson, L., Hoglund, A., Hagenkort, A., Pham, T., Altun, M., Gaugaz, F.Z., Vikingsson, S., Evers, B., Henriksson, M., Vallin, K.S., Wallner, O.A., Hammarstrom, L.G., Wiita, E., Almlof, I., Kalderen, C., Axelsson, H., Djureinovic, T., Puigvert, J.C., Haggblad, M., Jeppsson, F., Martens, U., Lundin, C., Lundgren, B., Granelli, I., Jensen, A.J., Artursson, P., Nilsson, J.A., Stenmark, P., Scobie, M., Berglund, U.W., Helleday, T.
Nature
HeaderHydrolase/Hydrolase Inhibitor
Released2013-10-04
Resolution1.600
CATH Insert Date20 Apr, 2014

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 21 Apr, 2014 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4n1tA00 25 Apr, 2014 3.90.79.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P36639 8ODP_HUMAN Homo sapiens 7,8-dihydro-8-oxoguanine triphosphatase
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