Discovery of 7-tetrahydropyran-2-yl chromans: beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid beta-protein (A beta ) in the central nervous system.
Thomas, A.A., Hunt, K.W., Volgraf, M., Watts, R.J., Liu, X., Vigers, G., Smith, D., Sammond, D., Tang, T.P., Rhodes, S.P., Metcalf, A.T., Brown, K.D., Otten, J.N., Burkard, M., Cox, A.A., Do, M.K., Dutcher, D., Rana, S., DeLisle, R.K., Regal, K., Wright, A.D., Groneberg, R., Scearce-Levie, K., Siu, M., Purkey, H.E., Lyssikatos, J.P., Gunawardana, I.W.
J.Med.Chem.
