PDB Information

PDB4M6P
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Zheng, X., Bair, K.W., Bauer, P., Baumeister, T., Bowman, K.K., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Feng, Y., Han, B., Ho, Y.C., Kley, N., Li, H., Liang, X., Liederer, B.M., Lin, J., Ly, J., O'Brien, T., Oeh, J., Oh, A., Reynolds, D.J., Sampath, D., Sharma, G., Skelton, N., Smith, C.C., Tremayne, J., Wang, L., Wang, W., Wang, Z., Wu, H., Wu, J., Xiao, Y., Yang, G., Yuen, P.W., Zak, M., Dragovich, P.S.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2013-08-10
Resolution1.750
CATH Insert Date29 Sep, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 30 Sep, 2013 Chopped
B 30 Sep, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4m6pA01 02 Oct, 2013 Holding pen
4m6pA02 02 Oct, 2013 3.20.20.70 Assigned
4m6pB01 01 Oct, 2013 Holding pen
4m6pB02 01 Oct, 2013 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
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