PDB Information

PDB4L53
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics.
Hornberger, K.R., Chen, X., Crew, A.P., Kleinberg, A., Ma, L., Mulvihill, M.J., Wang, J., Wilde, V.L., Albertella, M., Bittner, M., Cooke, A., Kadhim, S., Kahler, J., Maresca, P., May, E., Meyn, P., Romashko, D., Tokar, B., Turton, R.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2013-06-10
Resolution2.550
CATH Insert Date04 Aug, 2013

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Aug, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4l53A01 14 Aug, 2013 3.30.200.20 Assigned
4l53A02 14 Aug, 2013 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q15750 TAB1_HUMAN Homo sapiens TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
O43318 M3K7_HUMAN Homo sapiens Mitogen-activated protein kinase kinase kinase 7