PDB 4k9h

PDB Links
Overview

PDB Information

PDB	4K9H
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Pennington, L.D., Whittington, D.A., Bartberger, M.D., Jordan, S.R., Monenschein, H., Nguyen, T.T., Yang, B.H., Xue, Q.M., Vounatsos, F., Wahl, R.C., Chen, K., Wood, S., Citron, M., Patel, V.F., Hitchcock, S.A., Zhong, W. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-04-19
Resolution	2.290
CATH Insert Date	04 Aug, 2013

PDB Images (10)

Image of CATH 4k9h

4k9h

PDB 4k9h

Image of CATH 4k9hA

4k9hA

PDB Chain 4k9hA

Image of CATH 4k9hB

4k9hB

PDB Chain 4k9hB

Image of CATH 4k9hC

4k9hC

PDB Chain 4k9hC

Image of CATH 4k9hA01

4k9hA01

CATH Domain 4k9hA01

Image of CATH 4k9hA02

4k9hA02

CATH Domain 4k9hA02

Image of CATH 4k9hB01

4k9hB01

CATH Domain 4k9hB01

Image of CATH 4k9hB02

4k9hB02

CATH Domain 4k9hB02

Image of CATH 4k9hC01

4k9hC01

CATH Domain 4k9hC01

Image of CATH 4k9hC02

4k9hC02

CATH Domain 4k9hC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	05 Aug, 2013	Chopped
B	05 Aug, 2013	Chopped
C	05 Aug, 2013	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4k9hA01	14 Aug, 2013	2.40.70.10	Assigned
4k9hA02	14 Aug, 2013	2.40.70.10	Assigned
4k9hB01	14 Aug, 2013	2.40.70.10	Assigned
4k9hB02	14 Aug, 2013	2.40.70.10	Assigned
4k9hC01	14 Aug, 2013	2.40.70.10	Assigned
4k9hC02	14 Aug, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1