PDB 4k4e

PDB Information

PDB4K4E
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
Bregman, H., Chakka, N., Guzman-Perez, A., Gunaydin, H., Gu, Y., Huang, X., Berry, V., Liu, J., Teffera, Y., Huang, L., Egge, B., Mullady, E.L., Schneider, S., Andrews, P.S., Mishra, A., Newcomb, J., Serafino, R., Strathdee, C.A., Turci, S.M., Wilson, C., Dimauro, E.F.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-04-12
Resolution2.300
CATH Insert Date07 Jul, 2013

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped
B 08 Jul, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4k4eA00 09 Aug, 2013 3.90.228.10 Assigned
4k4eB00 09 Aug, 2013 3.90.228.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1