PDB 4k3j

PDB Information

PDB4K3J
MethodX-RAY DIFFRACTION
Host OrganismTrichoplusia ni
Gene SourceHomo sapiens
Primary Citation
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Merchant, M., Ma, X., Maun, H.R., Zheng, Z., Peng, J., Romero, M., Huang, A., Yang, N.Y., Nishimura, M., Greve, J., Santell, L., Zhang, Y.W., Su, Y., Kaufman, D.W., Billeci, K.L., Mai, E., Moffat, B., Lim, A., Duenas, E.T., Phillips, H.S., Xiang, H., Young, J.C., Vande Woude, G.F., Dennis, M.S., Reilly, D.E., Schwall, R.H., Starovasnik, M.A., Lazarus, R.A., Yansura, D.G.
Proc.Natl.Acad.Sci.USA
HeaderTransferase/Immune System/Growth Factor
Released2013-04-10
Resolution2.800
CATH Insert Date15 Sep, 2013

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 16 Sep, 2013 Chopped
B 16 Sep, 2013 Chopped
H 16 Sep, 2013 Chopped
L 16 Sep, 2013 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4k3jA01 18 Sep, 2013 2.40.10.10 Assigned
4k3jA02 18 Sep, 2013 2.40.10.10 Assigned
4k3jB01 18 Sep, 2013 2.130.10.10 Assigned
4k3jB02 18 Sep, 2013 3.30.1680.10 Assigned
4k3jH01 18 Sep, 2013 2.60.40.10 Assigned
4k3jH02 18 Sep, 2013 2.60.40.10 Assigned
4k3jL01 18 Sep, 2013 2.60.40.10 Assigned
4k3jL02 18 Sep, 2013 2.60.40.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P08581 MET_HUMAN Homo sapiens Hepatocyte growth factor receptor
P14210 HGF_HUMAN Homo sapiens Hepatocyte growth factor