PDB 4jps
PDB Information
PDB | 4JPS |
Method | X-RAY DIFFRACTION |
Host Organism | Spodoptera frugiperda |
Gene Source | Homo sapiens |
Primary Citation | Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Bioorg.Med.Chem.Lett.
|
Header | Transferase/Transferase Inhibitor |
Released | 2013-03-19 |
Resolution | 2.200 |
CATH Insert Date | 06 Apr, 2014 |
PDB Images (10)
PDB Prints
PDB Chains (2)
Chain ID | Date inserted into CATH | CATH Status |
---|---|---|
A | 07 Apr, 2014 | Chopped |
B | 07 Apr, 2014 | Chopped |
CATH Domains (7)
Domain ID | Date inserted into CATH | Superfamily | CATH Status |
---|---|---|---|
4jpsA01 | 17 Apr, 2014 | 3.10.20.770 | Assigned |
4jpsA02 | 17 Apr, 2014 | 2.60.40.150 | Assigned |
4jpsA03 | 17 Apr, 2014 | 1.25.40.70 | Assigned |
4jpsA04 | 17 Apr, 2014 | 3.30.1010.10 | Assigned |
4jpsA05 | 17 Apr, 2014 | 1.10.1070.11 | Assigned |
4jpsB01 | 14 Nov, 2017 | Cathedral cath submit | |
4jpsB02 | 14 Nov, 2017 | 1.10.287.1490 | Assigned |
UniProtKB Entries (2)
Accession | Gene ID | Taxon | Description |
---|---|---|---|
P42336 | PK3CA_HUMAN | Homo sapiens | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
P27986 | P85A_HUMAN | Homo sapiens | Phosphatidylinositol 3-kinase regulatory subunit alpha |