PDB Information

PDB4JPE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species.
Hunt, K.W., Cook, A.W., Watts, R.J., Clark, C.T., Vigers, G., Smith, D., Metcalf, A.T., Gunawardana, I.W., Burkard, M., Cox, A.A., Geck Do, M.K., Dutcher, D., Thomas, A.A., Rana, S., Kallan, N.C., DeLisle, R.K., Rizzi, J.P., Regal, K., Sammond, D., Groneberg, R., Siu, M., Purkey, H., Lyssikatos, J.P., Marlow, A., Liu, X., Tang, T.P.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2013-03-19
Resolution1.800
CATH Insert Date07 Jul, 2013

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4jpeA01 09 Aug, 2013 2.40.70.10 Assigned
4jpeA02 09 Aug, 2013 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1