PDB 4jib

PDB Links
Overview

PDB Information

PDB	4JIB
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Plummer, M.S., Cornicelli, J., Roark, H., Skalitzky, D.J., Stankovic, C.J., Bove, S., Pandit, J., Goodman, A., Hicks, J., Shahripour, A., Beidler, D., Lu, X.K., Sanchez, B., Whitehead, C., Sarver, R., Braden, T., Gowan, R., Shen, X.Q., Welch, K., Ogden, A., Sadagopan, N., Baum, H., Miller, H., Banotai, C., Spessard, C., Lightle, S. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-03-05
Resolution	1.720
CATH Insert Date	07 Jul, 2013

PDB Images (9)

Image of CATH 4jib

4jib

PDB 4jib

Image of CATH 4jibA

4jibA

PDB Chain 4jibA

Image of CATH 4jibB

4jibB

PDB Chain 4jibB

Image of CATH 4jibC

4jibC

PDB Chain 4jibC

Image of CATH 4jibD

4jibD

PDB Chain 4jibD

Image of CATH 4jibA00

4jibA00

CATH Domain 4jibA00

Image of CATH 4jibB00

4jibB00

CATH Domain 4jibB00

Image of CATH 4jibC00

4jibC00

CATH Domain 4jibC00

Image of CATH 4jibD00

4jibD00

CATH Domain 4jibD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	08 Jul, 2013	Chopped
B	08 Jul, 2013	Chopped
C	08 Jul, 2013	Chopped
D	08 Jul, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4jibA00	09 Aug, 2013	1.10.1300.10	Assigned
4jibB00	09 Aug, 2013	1.10.1300.10	Assigned
4jibC00	09 Aug, 2013	1.10.1300.10	Assigned
4jibD00	09 Aug, 2013	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase