PDB 4int

PDB Links
Overview

PDB Information

PDB	4INT
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-01-06
Resolution	2.900
CATH Insert Date	03 Feb, 2013

PDB Images (57)

4int

PDB 4int

4inta

PDB Chain 4inta

4intA

PDB Chain 4intA

4intb

PDB Chain 4intb

4intB

PDB Chain 4intB

4intC

PDB Chain 4intC

4intD

PDB Chain 4intD

4intE

PDB Chain 4intE

4intF

PDB Chain 4intF

4intG

PDB Chain 4intG

4intH

PDB Chain 4intH

4intI

PDB Chain 4intI

4intJ

PDB Chain 4intJ

4intK

PDB Chain 4intK

4intL

PDB Chain 4intL

4intM

PDB Chain 4intM

4intN

PDB Chain 4intN

4intO

PDB Chain 4intO

4intP

PDB Chain 4intP

4intQ

PDB Chain 4intQ

4intR

PDB Chain 4intR

4intS

PDB Chain 4intS

4intT

PDB Chain 4intT

4intU

PDB Chain 4intU

4intV

PDB Chain 4intV

4intW

PDB Chain 4intW

4intX

PDB Chain 4intX

4intY

PDB Chain 4intY

4intZ

PDB Chain 4intZ

4inta00

CATH Domain 4inta00

4intA00

CATH Domain 4intA00

4intb00

CATH Domain 4intb00

4intB00

CATH Domain 4intB00

4intC00

CATH Domain 4intC00

4intD00

CATH Domain 4intD00

4intE00

CATH Domain 4intE00

4intF00

CATH Domain 4intF00

4intG00

CATH Domain 4intG00

4intH00

CATH Domain 4intH00

4intI00

CATH Domain 4intI00

4intJ00

CATH Domain 4intJ00

4intK00

CATH Domain 4intK00

4intL00

CATH Domain 4intL00

4intM00

CATH Domain 4intM00

4intN00

CATH Domain 4intN00

4intO00

CATH Domain 4intO00

4intP00

CATH Domain 4intP00

4intQ00

CATH Domain 4intQ00

4intR00

CATH Domain 4intR00

4intS00

CATH Domain 4intS00

4intT00

CATH Domain 4intT00

4intU00

CATH Domain 4intU00

4intV00

CATH Domain 4intV00

4intW00

CATH Domain 4intW00

4intX00

CATH Domain 4intX00

4intY00

CATH Domain 4intY00

4intZ00

CATH Domain 4intZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	04 Feb, 2013	Chopped
A	04 Feb, 2013	Chopped
b	04 Feb, 2013	Chopped
B	04 Feb, 2013	Chopped
C	04 Feb, 2013	Chopped
D	04 Feb, 2013	Chopped
E	04 Feb, 2013	Chopped
F	04 Feb, 2013	Chopped
G	04 Feb, 2013	Chopped
H	04 Feb, 2013	Chopped
I	04 Feb, 2013	Chopped
J	04 Feb, 2013	Chopped
K	04 Feb, 2013	Chopped
L	04 Feb, 2013	Chopped
M	04 Feb, 2013	Chopped
N	04 Feb, 2013	Chopped
O	04 Feb, 2013	Chopped
P	04 Feb, 2013	Chopped
Q	04 Feb, 2013	Chopped
R	04 Feb, 2013	Chopped
S	04 Feb, 2013	Chopped
T	04 Feb, 2013	Chopped
U	04 Feb, 2013	Chopped
V	04 Feb, 2013	Chopped
W	04 Feb, 2013	Chopped
X	04 Feb, 2013	Chopped
Y	04 Feb, 2013	Chopped
Z	04 Feb, 2013	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4inta00	11 Feb, 2013	3.60.20.10	Assigned
4intA00	11 Feb, 2013	3.60.20.10	Assigned
4intb00	11 Feb, 2013	3.60.20.10	Assigned
4intB00	11 Feb, 2013	3.60.20.10	Assigned
4intC00	11 Feb, 2013	3.60.20.10	Assigned
4intD00	11 Feb, 2013	3.60.20.10	Assigned
4intE00	11 Feb, 2013	3.60.20.10	Assigned
4intF00	11 Feb, 2013	3.60.20.10	Assigned
4intG00	11 Feb, 2013	3.60.20.10	Assigned
4intH00	11 Feb, 2013	3.60.20.10	Assigned
4intI00	11 Feb, 2013	3.60.20.10	Assigned
4intJ00	11 Feb, 2013	3.60.20.10	Assigned
4intK00	11 Feb, 2013	3.60.20.10	Assigned
4intL00	11 Feb, 2013	3.60.20.10	Assigned
4intM00	11 Feb, 2013	3.60.20.10	Assigned
4intN00	11 Feb, 2013	3.60.20.10	Assigned
4intO00	11 Feb, 2013	3.60.20.10	Assigned
4intP00	11 Feb, 2013	3.60.20.10	Assigned
4intQ00	11 Feb, 2013	3.60.20.10	Assigned
4intR00	11 Feb, 2013	3.60.20.10	Assigned
4intS00	11 Feb, 2013	3.60.20.10	Assigned
4intT00	11 Feb, 2013	3.60.20.10	Assigned
4intU00	11 Feb, 2013	3.60.20.10	Assigned
4intV00	11 Feb, 2013	3.60.20.10	Assigned
4intW00	11 Feb, 2013	3.60.20.10	Assigned
4intX00	11 Feb, 2013	3.60.20.10	Assigned
4intY00	11 Feb, 2013	3.60.20.10	Assigned
4intZ00	11 Feb, 2013	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4