PDB Information

PDB4HYU
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Palmer, W.S., Alam, M., Arzeno, H.B., Chang, K.C., Dunn, J.P., Goldstein, D.M., Gong, L., Goyal, B., Hermann, J.C., Hogg, J.H., Hsieh, G., Jahangir, A., Janson, C., Jin, S., Ursula Kammlott, R., Kuglstatter, A., Lukacs, C., Michoud, C., Niu, L., Reuter, D.C., Shao, A., Silva, T., Trejo-Martin, T.A., Stein, K., Tan, Y.C., Tivitmahaisoon, P., Tran, P., Wagner, P., Weller, P., Wu, S.Y.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2012-11-14
Resolution2.150
CATH Insert Date03 Nov, 2013

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 04 Nov, 2013 Chopped
B 04 Nov, 2013 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4hyuA01 06 Nov, 2013 3.30.200.20 Assigned
4hyuA02 06 Nov, 2013 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P45983 MK08_HUMAN Homo sapiens Mitogen-activated protein kinase 8
Q9UQF2 JIP1_HUMAN Homo sapiens C-Jun-amino-terminal kinase-interacting protein 1