PDB 4heu

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Overview

PDB Information

PDB	4HEU
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux. Rzasa, R.M., Hu, E., Rumfelt, S., Chen, N., Andrews, K.L., Chmait, S., Falsey, J.R., Zhong, W., Jones, A.D., Porter, A., Louie, S.W., Zhao, X., Treanor, J.J., Allen, J.R. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-10-04
Resolution	2.000
CATH Insert Date	30 Dec, 2012

PDB Images (5)

Image of CATH 4heu

4heu

PDB 4heu

Image of CATH 4heuA

4heuA

PDB Chain 4heuA

Image of CATH 4heuB

4heuB

PDB Chain 4heuB

Image of CATH 4heuA00

4heuA00

CATH Domain 4heuA00

Image of CATH 4heuB00

4heuB00

CATH Domain 4heuB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	31 Dec, 2012	Chopped
B	31 Dec, 2012	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4heuA00	08 Feb, 2013	1.10.1300.10	Assigned
4heuB00	08 Feb, 2013	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A