Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation.
Mandal, M., Zhu, Z., Cumming, J.N., Liu, X., Strickland, C., Mazzola, R.D., Caldwell, J.P., Leach, P., Grzelak, M., Hyde, L., Zhang, Q., Terracina, G., Zhang, L., Chen, X., Kuvelkar, R., Kennedy, M.E., Favreau, L., Cox, K., Orth, P., Buevich, A., Voigt, J., Wang, H., Kazakevich, I., McKittrick, B.A., Greenlee, W., Parker, E.M., Stamford, A.W.
J.Med.Chem.