PDB Information

PDB4EZJ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Sutherlin, D.P., Baker, S., Bisconte, A., Blaney, P.M., Brown, A., Chan, B.K., Chantry, D., Castanedo, G., DePledge, P., Goldsmith, P., Goldstein, D.M., Hancox, T., Kaur, J., Knowles, D., Kondru, R., Lesnick, J., Lucas, M.C., Lewis, C., Murray, J., Nadin, A.J., Nonomiya, J., Pang, J., Pegg, N., Price, S., Reif, K., Safina, B.S., Salphati, L., Staben, S., Seward, E.M., Shuttleworth, S., Sohal, S., Sweeney, Z.K., Ultsch, M., Waszkowycz, B., Wei, B.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2012-05-02
Resolution2.670
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
4ezjA01 04 Sep, 2013 3.10.20.90 Assigned
4ezjA02 04 Sep, 2013 2.60.40.150 Assigned
4ezjA03 04 Sep, 2013 1.25.40.70 Assigned
4ezjA04 04 Sep, 2013 3.30.1010.10 Assigned
4ezjA05 04 Sep, 2013 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform