Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations.
Johnson, T.W., Richardson, P.F., Bailey, S., Brooun, A., Burke, B.J., Collins, M.R., Cui, J.J., Deal, J.G., Deng, Y.L., Dinh, D.M., Engstrom, L.D., He, M., Hoffman, J.E., Hoffman, R.L., Huang, Q., Kath, J., Kania, R.S., Lam, H., Lam, J.L., Le, P.T., Lingardo, L., Liu, W., Mctigue, M.A., Palmer, C.L., Sach, N.W., Smeal, T., Smith, G.L., Stewart, A.E., Timofeevski, S.L., Zhu, H., Zhu, J., Zou, H.Y., Edwards, M.P.
J.Med.Chem.
